通过液体活检检查肺腺癌的生物标志物microRNA分析的研究趋势:一本图书识别分析
Aprilia I Kartika1,2, Muchamad Dafip1, Nastiti Wijayanti3
1Biotechnology Doctorate Study Program, Graduate School, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Narra J
|May 12, 2025
概括
这项研究映射了微RNA作为肺腺癌生物标志物的研究. 虽然对早期检测有希望,但对于特定的microRNA和影响因素需要进一步验证.
科学领域:
- 生物标志物发现发现
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 肺腺癌的诊断依赖于有效的生物标志物.
- 微RNA具有作为诊断标记物的潜力,但需要对特定人群进行验证.
- 研究在分析和验证方法上有所不同.
研究的目的:
- 对微RNA作为肺腺癌生物标志物的出版物进行文献计量分析.
- 确定该领域的研究趋势和差距.
主要方法:
- 在多个数据库 (Crossref,谷歌学者,语义学者,PubMed,Scopus) 进行系统的文献搜索.
- 使用哈尔津的发布或灭亡,VOSviewer和Biblioshiny进行数据分析.
- 对692篇相关文章进行了文献计量分析.
主要成果:
- 确定了四个关键研究集群:微RNA,肺腺癌,液体活检和生物信息学.
- 微RNA是肺癌诊断,检测和理解转移的核心.
- 通过液体活检和计算分析在非侵入性诊断方面取得了重大进展.
结论:
- 微RNA对早期肺癌的检测和诊断具有很大的前景.
- 报告的microRNA类型中的不一致性需要进一步验证.
- 未来的研究应该专注于验证特定的microRNA及其对环境的影响.
相关概念视频
01:22MicroRNAs
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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