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治疗细菌性阴道炎和预防其复发的有效益生菌疗法:系统性审查
Udjianto Udjianto1,2, Noorhamdani A Sirat3, Bambang Rahardjo4
1Doctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Narra J
|May 12, 2025
概括
益生菌在细菌性阴道炎 (BV) 治疗方面表现有前途. 乳杆菌 rhamnosus TOM 22.8 在10×10^9 CFU/天10天似乎是最有效的,改善关键指标和减少复发.
科学领域:
- 微生物学 微生物学
- 妇科 妇科医生 妇科
- 药理学 药理学是指药理学的学科.
背景情况:
- 细菌性阴道炎 (BV) 是一种常见的阴道疾病,治疗选择有限.
- 益生菌为BV提供了潜在的替代或辅助疗法.
- 对BV的最佳益生菌物种,菌株,剂量和长期安全数据尚未得到充分确立.
研究的目的:
- 系统地评估益生菌对治疗细菌性阴道炎 (BV) 的有效性.
- 为了确定最佳的益生菌物种,菌株,剂量和治疗时间对BV.
- 评估与 BV 益生菌使用相关的临床结果,复发率和副作用.
主要方法:
- 在2014-2024年间发表在Scopus,Web of Science和PubMed.Med上的随机对照试验 (RCT) 的系统搜索.
- 使用的关键词:"阴道炎"",细菌性阴道炎"和"益生菌".
- 数据提取和合成,使用Risk of Bias 2工具进行质量评估,并使用NVivo 14软件进行主题分析.
主要成果:
- 包括16个RCT. 乳杆菌 rhamnosus TOM 22.8 (10×10^9 CFU/天长达10天) 显著改善了努根特评分,阴道pH和微生物群,减少了BV复发.
- 其他菌株如L. crispatus,L. plantarum和L. acidophilus在不同剂量 (1×10^8至5.4×10^9 CFU/天) 和持续时间 (6天至4个月) 中表现出潜力.
- 报告的副作用是轻微的和自我限制的.
结论:
- 益生菌可以被认为是细菌性阴道炎的辅助或替代治疗方法.
- 建议根据患者的特征进行个性化的益生菌选择方法.
- 需要进一步的大规模,标准化试验来完善对BV的益生菌建议.
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