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益生菌,益生菌,共生菌和后生菌对儿科喘的影响:系统性审查
Die Fan1, Jilei Hu1, Ning Lin1
1Clinical Nutrition, The General Hospital of Western Theater Command, Chengdu, China.
Frontiers in nutrition
|May 12, 2025
概括
针对微生物群的疗法,如益生菌,通过减少恶化和改善肺功能,在治疗儿科喘方面表现有前途. 需要进一步的研究来规范协议,并探索益生菌的疗效.
科学领域:
- 微生物组研究的研究.
- 儿科免疫学 儿科免疫学
- 呼吸系统药物 呼吸系统药物
背景情况:
- 儿童喘是一个日益严重的全球健康问题,带来了巨大的负担.
- 肠肺轴和微生物群失生症在喘发病过程中越来越被认可.
- 针对微生物群的治疗方法提供了一种新的治疗途径.
研究的目的:
- 系统地审查益生菌,益生菌,共生菌和后生菌在儿科喘中的疗效和安全性.
- 评估这些干预措施对喘控制和相关生物标志物的影响.
主要方法:
- 在2025年1月之前对主要数据库 (PubMed,Cochrane,Web of Science,Embase) 进行全面的系统搜索.
- 包括患有喘的儿童和青少年 (<18岁) 的随机对照试验 (RCT).
- 对18项研究 (13项RCT,n=2,419) 的分析,重点是微生物群调节剂.
主要成果:
- 益生菌 (Lactobacillus,Bifidobacterium) 显著减少了喘恶化,改善了肺功能.
- 后生物质 (细菌溶解物) 减弱了呼吸道过敏反应和炎症.
- 协生菌降低了病毒感染和医疗保健的使用; 益生菌的疗效仍未得到充分研究.
- 在剂量和持续时间方面存在显著的异质性,在几个研究中存在明显的偏差风险.
结论:
- 针对微生物群的治疗表明了儿童喘管理的潜力.
- 标准化的协议,菌株特定的研究和专门的益生菌研究至关重要.
- 未来的研究应该纳入个性化干预策略的多主题.
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