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在患有慢性腹的患者中,外分胰腺功能衰竭的患病率
Tara Keihanian1, Suneal Agarwal1, Nabil Mansour1
1Department of Medicine, Division of Gastroenterology, Baylor College of Medicine, Houston, Texas, USA.
Saudi journal of medicine & medical sciences
|May 12, 2025
概括
在慢性腹 (CD) 患者中,外分胰腺功能不全 (EPI) 经常被忽视. 用便弹性酶 (FE) 查可以识别EPI,9.3%的CD患者显示低FE水平.
科学领域:
- 胃肠病学 胃肠病学
- 消化系统健康 消化系统健康
- 胰腺疾病 胰腺疾病
背景情况:
- 外分胰腺功能缺陷 (EPI) 在出现新发慢性腹 (CD) 的患者中经常被诊断不足.
- 早期发现EPI对于CD患者的有效治疗和症状缓解至关重要.
研究的目的:
- 为了确定EPI在患有新发慢性腹的患者中的患病率.
- 评估便弹性酶 (FE) 测试作为该人群中EPI的初始查工具的有用性.
主要方法:
- 一项前性单中心研究在2018年至2021年期间招募了新发性CD (持续时间≥4周) 的患者.
- 进行了便延酶 (FE) 测试,低水平 (<200μg/g) 促使进行72小时便脂肪测试.
- 收集和分析了人口和临床数据,以确定与低FE水平相关的因素.
主要成果:
- 在97名患者身上进行了便弹性酶测试,在9名患者中发现了低FE (9.3%的患病率).
- 与正常FE患者相比,低FE患者的平均体重显著增加.
- 在9名接受治疗的患者中,胰腺酶治疗导致6名患者的症状完全消失,其中3名患者中有2名确诊患有低FE.
结论:
- 这项研究表明,新发性CD患者中EPI的患病率为9.3%.
- 使用便FE测试对EPI进行查应被视为慢性腹患者初步诊断工作的一部分.
- 及时诊断和治疗EPI可以显著改善患者的治疗结果和生活质量.
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