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使用发酵大豆产品 (ImmuBalanceTM) 治疗慢性子宫内膜炎的新策略
Fumio Suyama1, Koji Nakagawa1, Keisuke Shiobara1
1Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, Japan.
Journal of reproduction & infertility
|May 12, 2025
概括
免疫平衡 (IMB),一个前和益生菌,显示在治疗慢性子宫内膜炎 (CE) 的承诺,当抗生素失败. 它显著降低了患者的CD138计数,这表明了CE和重复植入失败 (RIF) 的新疗法选择.
科学领域:
- 生殖医学 生殖医学
- 微生物组研究 微生物组研究
- 妇科病理学 妇科病理学
背景情况:
- 慢性子宫内膜炎 (CE) 是重复植入失败 (RIF) 的重要因素.
- 对于CE的标准抗生素治疗并不总是导致解决.
- 对于持续的CE病例,需要使用替代疗法.
研究的目的:
- 调查Immubalance (IMB) 作为慢性子宫内膜炎 (CE) 的替代治疗方法的疗效,这是一个前和益生菌组合.
- 评估IMB在对常规抗生素治疗无反应的CE患者中的有效性.
主要方法:
- 一项回顾性研究分析了2021年4月至2022年8月期间患有CE的819名女性.
- 患者最初接受了多西环林或IMB的治疗.
- 随后的治疗包括不同的抗生素疗法或IMB对不响应病例,评估CD138+血细胞计数.
主要成果:
- 免疫平衡 (IMB) 治疗导致CD138+血细胞在2组和3组显著减少 (分别p<0.01和p=0.04).
- 在2组和3组 (15/15和4/4组) 中,100%的IMB治疗患者实现了CE解析.
- 在第一组的IMB初始使用显示了60%的解决率,尽管在统计学上并不显著 (p=0.13).
结论:
- 免疫平衡 (IMB) 显示出作为慢性子宫内膜炎 (CE) 有效治疗的潜力.
- 对于那些没有对抗生素治疗有反应的患者来说,IMB可能特别有益.
- 这项研究表明,IMB是管理CE的可行选择,可能改善RIF的结果.
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