血清叶酸预测了在症状性大动脉动脉瘤剖析中术前大动脉破裂:一个前性,单中心的观察性研究
Feier Song1, Zhengbo Chen2, Zhibo Yang3
1Department of Emergency Medicine and Emergency Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People's Republic of China.
International journal of general medicine
|May 12, 2025
概括
高血清叶酸水平与有症状的大动脉动脉瘤或剖析的患者中大动脉破裂的风险增加有关. 这一发现有助于对关键心血管事件的早期风险分层.
科学领域:
- 心血管医学 心血管医学
- 生物化学 生物化学
背景情况:
- 叶酸代谢产物是各种疾病中确定的预后标志物.
- 有限的研究存在于血清叶酸和大动脉破裂之间的关联.
- 有症状的大动脉动脉瘤/解剖患者需要更好的手术前风险评估.
研究的目的:
- 调查血清叶酸水平对术前不良事件的预测价值.
- 评估血清叶酸作为有症状的大动脉动脉瘤/解剖患者的大动脉破裂的预测因素.
主要方法:
- 预计将639名有症状的大动脉动脉瘤/解剖症的患者纳入急诊室.
- 单变量和多变量逻辑回归分析以确定断裂预测因子.
- 开发一个包括叶酸水平和其他临床标志物在内的预后名录.
主要成果:
- 8.61%的患者经历了手术前的大动脉破裂,血清叶酸升高患者的发病率更高.
- 血清叶酸水平≥9 ng/mL是手术前大动脉破裂的独立风险因素 (OR=2.41).
- 一种组合大动脉剖析类型,叶酸,白血球,和葡萄糖的诺摩图显示出强大的预测能力 (AUC=0.801).
结论:
- 血清叶酸水平是症状性大动脉动脉瘤/剖析患者手术前大动脉破裂的独立预测指标.
- 开发的名图为在紧急情况下早期风险分层提供了一个实用的工具.
- 叶酸的预后价值,与其他临床标记一起,有助于管理高风险心血管患者.
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