从皮中提取的质素制成的绿色基,作为皮肤输送系统的潜在载体
Rania Hamed1, Kamar Hamdan Magamseh1, Eveen Al-Shalabi1
1Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman 11733, Jordan.
ACS omega
|May 12, 2025
概括
色皮的培根被开发成绿色的水凝用于局部使用. 虽然pectin水凝显示出作为皮肤载体的潜力,但乙醇色皮提取物表现出优越的伤口愈合和抗菌特性.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物技术是生物技术.
背景情况:
- 果物废弃物,特别是皮,是珍贵生物聚合物的可持续来源,如点.
- 是一种天然的多糖,由于其凝,稳定和加厚特性,在各种行业中广泛使用.
- 从自然来源开发环保载体对于可持续的局部药物输送系统至关重要.
研究的目的:
- 开发和特征绿色水凝从皮提取的花粉素用于局部应用.
- 评估开发的丁水凝的物理化学,学和生物粘合性质.
- 为了比较酸的生物活性 (抗氧化剂,抗微生物,伤口愈合) 与乙醇皮提取物.
主要方法:
- 素是从子皮中提取出来的,并以产量,雌性化程度,相当重量,甲氧基和银酸含量来表征.
- 使用不同度 (8-32%) 的pectin和化 (CaCl2) 度 (0-80%) 的水凝制成,pH值调整为3.5和8.5.
- 进行了物理化学,rheological (粘弹性质),生物粘合,抗氧化,抗微生物和伤口愈合等测试.
主要成果:
- 提取的点产量为14%,化程度为20%.
- pectin水凝表现出伪塑性行为,粘性弹性 (G'>G") 和生物粘合性,适合皮肤传递.
- 乙醇皮提取物表现出显著的抗氧化剂,抗微生物 (对抗金黄色葡萄球菌) 和伤口愈合活性,超过了点丁水凝.
结论:
- 从皮中提取的pectin水凝显示出作为局部药物递送系统的载体的希望.
- 乙醇子皮提取物在伤口愈合和抗菌应用方面具有显著的治疗潜力.
- 与活性提取物相结合的pectin水凝可以提高皮肤治疗效果.
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