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Updated: May 14, 2025

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package
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Published on: September 17, 2021

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分子动力学研究Trypanosoma cruzi二基酸脱酶复合体:对抑制剂影响的分析

Eldio G Santos1, Luiz A P Flores-Junior1, Camilo H S Lima2

  • 1Laboratório de Química Medicinal, Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ 24241-000, Brazil.

ACS omega
|May 12, 2025
PubMed
概括

开发用于查加斯病的新药非常重要. 这项研究揭示了连接体大小和活性部位的灵活性如何影响Trypanosoma cruzi dihydroorotate脱酶 (TcDHODH) 抑制,指导创建更有效的治疗方法.

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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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