怀孕中急性脂肪肝在第二个三个月呈现:一个系统的文献综述
Laurence Bourque1, Michèle Mahone1,2
1Division of Internal Medicine and Obstetrical Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Obstetric medicine
|May 12, 2025
概括
怀孕期的急性脂肪肝 (AFLP) 罕见但严重. 这种情况导致高比例的孕产妇并发症和胎儿/新生儿死亡,尽管经常呈现非特异性症状.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 产科 产科 产科 产科 产科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 妊娠急性脂肪肝 (AFLP) 是一种罕见但危及生命的产科并发症.
- 由于其时机和潜在的严重程度,第二季度的AFLP提出了独特的挑战.
研究的目的:
- 描述怀孕第二个三个月期间诊断的AFLP的临床特征和结果.
- 突出这一罕见疾病的诊断标准和管理影响.
主要方法:
- 文献综述确定了怀孕20至27周之间诊断的AFLP病例.
- 分析临床特征,诊断标准 (天海标准,肝脏活检),孕妇并发症和怀孕结果.
主要成果:
- 确定了14例第二季度AFLP病例,诊断发生在20至27+6周之间.
- 常见的孕产妇并发症包括功能衰竭,低血糖,肝功能衰竭,脑病变,ICU入院和输血.
- 观察到高死亡率:一个孕产妇死亡,7个胎儿死亡,3个新生儿死亡.
结论:
- 第二个三个月的AFLP是一种罕见的产科紧急情况,具有重大的孕产妇和胎儿风险.
- 虽然症状可能是非特异性的,但肝脏活检结果 (微血管稳定症) 和临床标准对于诊断至关重要.
- 由于高的孕产妇发病率和死亡率,迅速诊断和管理至关重要.
关键词:
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