综合饮食抗氧化剂指数与老年人认知功能障碍之间的关联:来自NHANES 2011-2014年的证据
Yingying Qian1, Qiang Liu1, Tianlang Li1
1Department of Geriatrics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Frontiers in neurology
|May 12, 2025
概括
通过综合饮食抗氧化剂指数 (CDAI) 测量的较高的饮食抗氧化剂摄入量与美国老年人更好的认知功能有关. 这项研究发现了一种保护性关联,表明CDAI可能有助于预测认知能力下降.
科学领域:
- 营养科学 营养科学
- 老年学是指老年学的学科.
- 认知神经科学 认知神经科学
背景情况:
- 富含抗氧化剂的饮食被认为具有保护认知功能下降的潜力.
- 综合饮食抗氧化剂指数 (CDAI) 量化了饮食中总体的抗氧化剂摄入量.
- 有限的研究已经探索了CDAI和认知障碍之间的直接联系.
研究的目的:
- 调查综合饮食抗氧化剂指数 (CDAI) 与美国老年人群认知功能障碍之间的关联.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据 (2011-2014).
- 多变量逻辑回归和受限立方线回归 (RCS) 来评估关系及其非线性.
- 为认知障碍概率开发一个风险预测名ogram模型.
主要成果:
- 认知能力较低的人往往有较低的CDAI分数.
- 在CDAI和认知障碍之间发现了显著的反向关联,特别是与CERAD单词学习子测试 (OR:0.94,95%CI:0.90-0.98).
- RCS曲线显示了CDAI和认知表现之间的平滑,L形相关性;名图显示了良好的预测值 (AUC=0.747).
结论:
- 在美国老年人中,CDAI和认知功能障碍之间存在非线性,负面的关联.
- 该研究开发了一种经过验证的nomogram模型,用于预测认知障碍风险.
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