多发性硬化症患者和健康对照者之间的月经期年龄是否不同? :一个更新的系统审查和元分析
Zahra Shahraki1, Mohsen Rastkar2,3, Elnaz Rastkar4
1Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran.
Journal of family & reproductive health
|May 12, 2025
概括
晚期初潮与患多发性硬化症 (MS) 的风险较低有关. 这项系统性审查发现,MS患者的初潮比对照组更早,从而加强了这种保护性关联.
科学领域:
- 生殖健康 生殖健康
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 性激素会影响自身免疫性疾病的发展,包括多发性硬化症 (MS).
- 以前的研究表明,初潮时的年龄与MS风险之间存在潜在联系.
研究的目的:
- 为了估计MS患者和对照患者之间初经期的综合平均年龄差异.
- 更新与初潮时年龄增加相关的发展MS的几率.
主要方法:
- 在PubMed,Scopus,EMBASE和Web of Science进行了全面的系统搜索.
- 在选了331篇全文文章后,包括了15项研究.
- 进行元分析以计算聚合的标准化平均差异 (SMD) 和几率比率 (OR).
主要成果:
- 在初潮时的年龄 (对照病例) 中,聚合的SMD为0.17 (95%CI:0.09-0.25),表明在对照中更晚的初潮.
- 对于发展多发性硬化症的综合OR,在初潮时每增加1年的年龄是0.92 (95% CI:0.89-0.94).
结论:
- 与对照组相比,患有多发性硬化症的女性在初潮时往往有较早的年龄.
- 初潮时的年龄增加与患多发性硬化症的风险降低有关.
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