较低的CALLY指数水平表明,急性缺血性中风患者治疗内血管血栓切除术的功能不良结局风险更高
Yunnan Lu1, Xiaohua Zhu1, Yaojia Xu2
1Department of Neurology, Xishan People's Hospital of Wuxi City, Wuxi, China.
Frontiers in aging neuroscience
|May 12, 2025
概括
较低的C-反应蛋白-白蛋白-淋巴细胞 (CALLY) 指数预测在内血管血栓切除术 (EVT) 后,急性缺血性中风 (AIS) 患者的功能表现不佳. 这一指数可以作为一个有价值的生物标志物,用于预测接受EVT的AIS患者的不良事件.
科学领域:
- 生物标志物 生物标志物
- 神经学 神经学
- 炎症研究 炎症研究
背景情况:
- 营养,免疫和炎症不平衡会影响疾病的预后.
- 反应性C蛋白-白蛋白-淋巴细胞 (CALLY) 指数反映了这些状态.
研究的目的:
- 评估CALLY指数与急性缺血性中风 (AIS) 患者治疗内血管血栓切除术 (EVT) 的结果之间的相关性.
主要方法:
- 对接受EVT的473名AIS患者的回顾性分析.
- 定义为修改的Rankin尺度得分> 2在90天后的功能性不良结果.
- 使用ROC曲线用于CALLY指数切线,多变量逻辑回归和受限制的立方线来分析关联.
主要成果:
- 在45.2%的患者中观察到不良的功能结果.
- 较低的CALLY指数与功能表现差显著相关 (OR:0.80,95%CI:0.70-0.91).
- 限制性立方线分析显示,CALLY指数与糟糕结果风险之间存在反向关联.
结论:
- 较低的CALLY指数独立地预测了EVT后的功能表现不佳.
- 卡利指数显示,作为一种实用的,具有成本效益的生物标志物,可用于在接受EVT的AIS患者的不良结果.
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