相关实验视频
Updated: May 14, 2025
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.5K
在甲状腺癌中重新编程脂肪酸代谢:潜在的目标和机制
Pengbin Ping1,2, Yuhong Ma1, Xiaoying Xu1
1Department of Radiotherapy Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.
概括
甲状腺癌 (TC) 研究正在探索脂肪酸 (FA) 代谢重编程如何影响瘤生长和耐药性. 了解这些代谢变化可能会揭示新的治疗点,攻击性TC.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 癌症新陈代谢 癌症新陈代谢
背景情况:
- 甲状腺癌 (TC) 发病率在全球范围内不断上升,大多数病例是可以治疗的,但有些病例表现出高度的攻击性.
- 目前的治疗方法,如氨酸激酶抑制剂,由于毒性和耐药性而面临局限性.
- 脂质代谢重编程,特别是脂肪酸 (FA) 代谢,在癌症发展中越来越被认可.
研究的目的:
- 审查脂肪酸 (FA) 代谢重编程在甲状腺癌 (TC) 发生和进展中的作用.
- 检查异常FA代谢途径和TC中的基因表达的影响.
- 通过分析FA代谢和癌症信号通路来确定新的治疗点.
主要方法:
- 文献综述侧重于甲状腺癌中FA代谢.
- 对FA代谢途径的基因表达和调控变化的分析.
- 检查FA代谢和致癌信号之间的相互作用.
主要成果:
- 在TC中,FA代谢重编程对于瘤生长,转移,入侵,免疫逃脱和药物耐药性至关重要.
- 异常的FA代谢途径和改变的基因表达与TC发展有关.
- 关联FA代谢与TC病变的特定机制需要进一步全面理解.
结论:
- 脂肪酸 (FA) 的代谢重编程是甲状腺癌 (TC) 进展和治疗耐药性的重要因素.
- 准FA代谢是一个有希望的策略,用于开发TC的新型,精确的疗法.
- 对FA代谢重编程机制的进一步研究对于推进TC治疗至关重要.
相关概念视频
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
01:18Functions of Thyroid Hormones
2.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.4K
01:20Synthesis and Regulation of Thyroid Hormones
4.0K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.0K
01:31Transducer Mechanism: Nuclear Receptors
1.2K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.2K
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.3K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.3K
02:38Mitogens and the Cell Cycle
6.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K