在芯片上的器官体外血管化的模型结构的进展
Hongze Yin1, Yue Wang2, Na Liu1,3,4
1School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.
Cyborg and bionic systems (Washington, D.C.)
|May 12, 2025
概括
工程微流体设备创建精确的体外血管网络用于研究疾病. 本综述涵盖了构建这些血管化芯片的方法以及未来的有机芯片方法.
科学领域:
- 生物医学工程 生物医学工程
- 细胞生物学 细胞生物学
- 微流体学 微流体学
背景情况:
- 微血管系统对于人类生理和疾病至关重要.
- 在体外血管网络对于研究血管组织行为至关重要.
- 基于微流体的3D微血管网络模型提供可重现的平台.
研究的目的:
- 审查微血管组织和微流体装置的 in vitro 策略的进展.
- 讨论分类,结构特征和血管化芯片的技术.
- 探索未来的方向,包括有机芯片血管化.
主要方法:
- 总结了微血管组织和微流体装置构建的最新进展.
- 根据结构和制造技术对静态血管化芯片进行分类.
- 在微通道,膜和水凝中审查体外血管生长的方法.
主要成果:
- 微流体设备可以模拟器官特定模型的体内微环境.
- 在体外血管可以使用静态或动态方法生长.
- 在微流体平台内构建血管化芯片存在各种技术.
结论:
- 工程微流体血管化芯片对于在体外研究微血管是必不可少的.
- 优化微流体设备可以提高器官芯片应用的生物相关性.
- 将有机体和器官芯片结合在一起,为先进的血管化提供了一个有希望的方法.
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