研究HbA1c与怀孕期间贫血的相关性
Shalini Mishra1, Vinita Das1, Smriti Agrawal1
1Faculty of Medical Sciences, King George's Medical University, Lucknow, Uttar Pradesh India.
Journal of obstetrics and gynaecology of India
|May 12, 2025
概括
贫血严重影响孕妇的血红蛋白A1c (HbA1c) 水平,影响妊娠期糖尿病 (GDM) 的诊断. 在贫血妇女中观察到更高的HbA1c,无论GDM状态如何,突出显示了贫血.
科学领域:
- 内分泌学 在内分泌学.
- 产科 产科 产科 产科 产科
- 生物化学 生物化学
背景情况:
- 血红蛋白A1c (HbA1c) 是评估2-3个月超血糖症的关键标志物.
- 美国糖尿病协会将HbA1c≥6.5%定义为糖尿病的诊断标准.
- 关于贫血对HbA1c水平的影响存在相互矛盾的证据.
研究的目的:
- 评估HbA1c与血红蛋白 (Hb) 结合用于诊断妊娠糖尿病 (GDM) 的实用性.
- 评估HbA1c作为高贫血患病率地区GDM查工具的潜力.
主要方法:
- 一项观察性研究涉及193名孕妇 (<16周怀孕) 超过一年.
- 血糖,HbA1c和Hb水平在三个产前检查时被测量.
- 参与者被分为糖尿病/非糖尿病和贫血/非贫血组.
主要成果:
- 孕期糖尿病 (GDM) 的患病率为32.1%.
- 贫血妇女的平均HbA1c水平明显高 (4.5%非糖尿病,5.1%GDM) 与非贫血妇女相比 (3.96%非糖尿病,4.6%GDM).
- 在GDM和非GDM组中,HbA1c与血红蛋白水平呈反相关性.
结论:
- 平均HbA1c水平在三个月内有所不同,并受到贫血的影响.
- 贫血导致糖尿病和非糖尿病孕妇的HbA1c水平升高.
- 贫血的存在使HbA1c用于GDM诊断和查的解释变得复杂.
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