在脊髓损伤患者中出现并发性睡眠障碍
Abdulghani Sankari1,2,3, Ahmad Aldwaikat1,2, Moustafa Habra1,2
1Department of Medicine, John D. Dingell VA Medical Center, Detroit, MI.
概括
睡眠呼吸障碍 (SDB) 在脊髓损伤 (SCI) 患者中非常普遍. 阳性气道压力 (PAP) 治疗在这个人群中显示出有限的疗效和不良的坚持.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
背景情况:
- 睡眠呼吸障碍 (SDB) 对脊髓损伤 (SCI) 患者来说是一个重大问题.
- 了解SCI中SDB的患病率和类型对于有效管理至关重要.
- 阳性气道压力 (PAP) 疗法是SDB的常见治疗方法,但其在SCI群体中的有效性需要进一步研究.
研究的目的:
- 确定患有SCI的个体中SDB的速率和类型.
- 评估PAP治疗在SCI患者治疗SDB中的疗效.
- 为了评估这个队列中对PAP治疗的坚持.
主要方法:
- 对患有慢性SCI (C4-T6水平) 的个人进行了诊断性多睡眠图 (PSG).
- SDB根据呼吸暂停-呼吸暂停指数 (AHI) 和中央呼吸暂停指数 (CAI) 被分为中央睡眠暂停 (CSA),阻塞性睡眠暂停 (OSA) 或联合 (COSA).
- 对PAP治疗的反应被评估为AHI<5事件/小时治疗后和90天的坚持.
主要成果:
- SDB的患病率很高,有85%的参与者被诊断出患有SDB的某种形式.
- 阻塞性睡眠呼吸暂停 (OSA) 是最常见的类型 (69%),其次是联合 (COSA) (15%) 和中央睡眠暂停 (CSA) 仅 (5%).
- 只有15%的患者在90天后对PAP治疗有反应,坚持显著下降.
结论:
- 睡眠呼吸障碍在脊髓损伤的个体中非常常见.
- 阳性气道压力疗法在SCI患者群体中显示出低于最佳的疗效和显著的坚持挑战.
- 需要进一步的研究,以优化SDB管理策略,以SCI的个人.
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