在精神病学中用于治疗的迷幻药的设置和设置:系统性审查
Clémentine Estric1, Thomas Duron2, Sarah Kabani3
1Department of Psychiatry, CHU Nîmes, University of Montpellier, Nîmes, France.
Journal of psychopharmacology (Oxford, England)
|May 12, 2025
概括
标准化迷幻疗法准备 (设置) 和环境 (设置) 对于精神病治疗至关重要. 本次审查强调了当前实践的变化,影响了研究可重复性和迷幻药物的有效性.
科学领域:
- 精神病学和精神药理学精神病学和精神药理学
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 迷幻物质在精神疾病中显示出显著的治疗潜力.
- 目前的研究缺乏参与者心理辅助治疗的准备 (设置) 和环境条件 (设置) 的标准化.
- 这种变异性阻碍了研究结果的解释和可重复性.
研究的目的:
- 系统地审查和描述精神疾病的迷幻药物的临床试验中的"设置"和"设置"参数.
- 评估设置和设置的关键元素在现有文献中报告的程度.
- 确定需要协调的领域,以改善未来的研究和临床应用.
主要方法:
- 在2023年12月之前,通过PubMed和Web of Science识别的英语或法语出版的临床试验的系统审查.
- 排除了专注于迷幻戒断的研究.
- 评估设置和设置的16个领域,包括参与者选择,干预,监测培训和环境管理.
主要成果:
- 包括27篇关于25项研究 (763名参与者) 的文章.
- 参与者选择和安全环境的创建都得到了一致的报告.
- 在报告监视员培训 (52%),视觉分心 (64%) 和愉快的环境 (68%) 中观察到显著的异质性. псилоцибин是研究最多的迷幻药 (47%).
结论:
- 虽然设置和设置的关键元素存在于迷幻研究中,但显著的差异限制了可比性和可重现性.
- 协调设置和设置协议对于在精神病学中推进对迷幻效应的理解至关重要.
- 标准化将有助于对未来临床试验结果进行更可靠的解释.
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