相关实验视频
Updated: May 13, 2025
08:36
In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
7.4K
针对瘤相关巨细胞的新兴疗法用于固体器官癌症的治疗
1Developmental Therapeutics Branch (TDB), Biology Group, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD, USA.
Expert opinion on emerging drugs
|May 12, 2025
概括
新兴的癌症疗法正在将重点从T细胞转移到瘤相关巨细胞 (TAMs). 抗TAM药物旨在重新编程,阻止招募或减少TAM,以增强抗瘤免疫力.
科学领域:
- 免疫瘤学 免疫瘤学
- 癌症免疫学 癌症免疫学
- 瘤微环境是一个微环境.
背景情况:
- 针对T细胞的免疫检查点抑制剂 (ICI) 是标准的癌症治疗.
- 瘤相关巨细胞 (TAMs) 是瘤微环境中的关键免疫抑制剂.
- 对基于T细胞的疗法的耐药性需要新的免疫瘤学方法.
研究的目的:
- 审查目前正在开发中的抗瘤相关巨细胞 (anti-TAM) 疗法.
- 在临床试验中突出针对TAM的新药候选者.
- 讨论新兴反TAM战略的行动机制.
主要方法:
- 对抗TAM疗法的正在进行的临床试验的审查.
- 对针对TAMs的不同治疗策略的分析.
- 专注于重新编程,招聘封锁和减少/取消TAM.
主要成果:
- 一些针对TAMs的新型免疫瘤学药物正在调查中.
- 在特定的癌症类型中,TAM重编程疗法显得有前途.
- 在先进的固体器官癌症中强大的有效性仍在调查中.
结论:
- 针对TAMs代表了免疫瘤学的下一个有希望的前沿.
- TAM重编程提供了潜在的好处,但疗效因癌症类型而异.
- 生物标志物驱动的方法对于克服TAM异质性和最大限度地发挥治疗潜力至关重要.
相关概念视频
01:27Tumor Immunotherapy
401
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
401
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
02:17The Tumor Microenvironment
6.4K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.4K