相关实验视频

Updated: May 13, 2025

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

口腔健康特征异构细胞移植后2年

L I Leinbach¹, S Boroumand¹, L R Masuch¹

¹National Institute of Dental & Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Journal of dental research

|May 12, 2025

概括

异质造血细胞移植的幸存者经历了持续的口腔健康问题,包括疼痛和干燥,影响了移植后两年的生活质量. 对这些患者来说,全面的长期口腔护理是必不可少的.

科学领域:

血液学血液学血液学
在瘤学瘤学.
口腔医学是指口腔医学.

背景情况:

全基血造细胞移植 (allo-HCT) 是对血液学疾病和癌症的拯救性治疗方法.
越来越多的alo-HCT幸存者面临着严重的口腔健康挑战,影响移植后的生活质量.

研究的目的:

在移植后两年内,对alo-HCT接受者的临床和患者报告的口腔健康结果进行表征.
为了确定持续的口腔健康问题及其对当代alo-HCT队列生活质量的影响.

主要方法:

在2019-2022年间移植的60名HCT参与者的前性队列研究.
在HCT后3,6,12,18和24个月收集临床和患者报告的结果.
进行了描述性和双变量统计分析.

主要成果:

在整个2年的随访期间,观察到口腔疼痛,异口,吞困难和味觉障碍的显著差异.
在HCT后2年,47.5%的人报告口腔疼痛,44.1%的人报告异口.
移植后2年,与味道,疼痛和有关的生活质量下降显而易见.

结论:

口腔健康问题和与口腔健康相关的生活质量下降持续至少两年.
调查结果强调,需要为所有HCT幸存者提供量身定制,全面和持续的口腔保健策略.

关键词:

癌症的生存率癌症的生存率牙科护理牙科护理与健康相关的生活质量.造血干细胞移植造血干细胞移植患者报告的结果.干细胞移植是干细胞移植.

更多相关视频

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

相关概念视频

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Cell-mediated Immune Responses

Cell-mediated Immune Responses