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Updated: May 23, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

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在乌比基结合酶中的素脱机制

Alexis J Wathan1, Nicole M Deschene2, Joseph M Litz2

  • 1Department of Science and Mathematics, Rochester Institute of Technology/NTID, Rochester, New York 14623, United States.

The journal of physical chemistry. B
|May 12, 2025
PubMed
概括

这项研究研究了Ubc13酶在ubiquitination中的化学机制. 模拟显示,Lys63 pKa对活动部位的近距离敏感,而不是附近的残留物,影响核激活.

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