在TAVR后的三年随访期间,生物假体门功能障碍的证据
Verena Veulemans1,2, Jacqueline Heermann3, Rik Adrichem4
1Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Medical Faculty, Moorenstr. 5, 40225, Düsseldorf, Germany. verena.veulemans@web.de.
概括
生物假肢功能障碍 (BVD) 在过导管大动脉置换 (TAVR) 后很常见,增加死亡率. 气球膨胀门显示更多的BVD,但死亡率在门类型中是相似的.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 生物材料科学 生物材料科学
背景情况:
- 通过导管的大动脉置换 (TAVR) 的使用在年轻,风险较低的患者中正在增加.
- 关于生物假体功能障碍 (BVD) 和设备差异的真实数据至关重要.
研究的目的:
- 评估BVD发生率,并比较TAVR后自扩展 (SEV) 和气球扩展 (BEV) 之间的结果.
- 为了在三年内在一个大规模的现实世界队列中评估BVD.
主要方法:
- 对1233名因三主动脉狭窄而接受TAVR的患者进行了回顾性多中心研究.
- 随访时间为三年,终点根据VARC-3标准定义.
- 在SEV和BEV之间比较BVD的发病率和类型 (SVD,NSVD,血栓形成).
主要成果:
- 五分之一 (22.4%) 的患者在三年内发展为BVD.
- 由于SVD和NSVD的比率更高,BVD与BEV (60.9%) 比SEV (39.1%) 更频繁.
- 亚临床传单血栓症仅在BEV (1.7%) 中发生. 在BVD+患者中,全因死亡率较高 (22.5%对13.2%).
结论:
- 生物假体门功能障碍是TAVR后的一个重大问题,与增加的死亡率有关.
- 虽然BEV显示出更高的BVD率,但SEV和BEV平台之间的三年死亡率没有显著差异.
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