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免疫检查点抑制剂与甲状腺炎相关:机制和临床结果
Sara S Hammerstad1,2, Hanna J Lee3, Yaron Tomer3
1Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, 4950, 0424, PB, Norway.
Journal of endocrinological investigation
|May 12, 2025
概括
免疫检查点抑制剂可以导致甲状腺功能障碍,这是一个常见的副作用. 本综述探讨了与这些免疫相关的不良事件相关的临床特征,机制和改善的生存率.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗,但可以引起与免疫相关的不良事件 (irAEs).
- 内分泌IRAE,特别是甲状腺功能障碍,很常见,影响约10%的患者,通常与PD-1/PD-L1阻塞有关.
- 甲状腺功能障碍呈现为甲状腺毒性症,其次是甲状腺功能低下症,与更好的癌症治疗反应和整体存活率相关.
研究的目的:
- 审查甲状腺免疫相关不良事件 (irAEs) 的临床特征.
- 讨论ICI诱导的甲状腺炎的潜在机制.
- 检查甲状腺IRAE与改善患者存活率之间的关联.
主要方法:
- 关于甲状腺irAEs的临床数据的文献综述.
- 对拟议的免疫和细胞机制的分析.
- 综合证据,将IRE与治疗结果联系起来.
主要成果:
- 甲状腺功能障碍是ICI治疗的常见内分泌IRAE,主要影响甲状腺.
- 最常见的表现包括过渡性甲状腺毒性,其次是甲状腺功能低下症.
- 在irAEs和对癌症治疗的增强反应之间存在显著的相关性,包括改善整体存活率.
结论:
- 甲状腺激发性瘤是ICI治疗的一个显著后果,需要临床关注.
- 甲状腺irrAEs的发展可能涉及遗传,免疫和内在的甲状腺细胞因素.
- 鉴于它们与癌症患者的良好治疗结果相关,监测和理解甲状腺IREs至关重要.
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