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在患有类风湿性关节炎的患者中IL-17A,IL-17F和IL-23

N A Lapkina¹, A A Baranov², O P Rechkina²

¹Yaroslavl State Medical University, Yaroslavl, Russia. lanaal@rambler.ru.

Doklady. Biochemistry and biophysics

|May 12, 2025

概括

在晚期类风湿性关节炎 (RA) 中,高联素-23 (IL-23) 是常见的,而IL-17A和IL-17F水平与对照相似. 高IL-17A与疾病活性指数和自身抗体相关.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
生物化学生物化学

背景情况:

类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特征是关节炎症.
互白蛋白 (ILs) 在RA病变发生过程中起着至关重要的作用,其中IL-17和IL-23通路是关键目标.
了解IL-17A,IL-17F和IL-23在晚期RA中的特定作用对于向治疗很重要.

研究的目的:

评估IL-17A,IL-17F和IL-23在晚期RA患者中的临床和诊断意义.
为了比较RA患者的血清细胞因子水平与健康对照.
调查这些细胞因子和RA疾病活动标志物之间的相关性.

主要方法:

分析了来自154名RA患者的血清样本 (ACR/EULAR 2010标准) 和20名健康捐赠者的血清样本.
使用多重xMAR技术量化IL-17A,IL-17F和IL-23水平.
收集了临床数据,包括疾病活性评分 (DAS28-ESR,CDAI,SDAI),类风湿性因子 (IgM RF) 和抗循环素抗体 (ACCP).

主要成果:

与对照组相比,RA患者的血清IL-23水平明显高 (p < 0.05).
在RA患者和对照人群中,IL-17A和IL-17F水平没有显著差异 (p > 0.05).
升高的IL-17A与较高的CDAI,SDAI,IgM RF和ACCP相关. 升高的IL-17F与更高的ESR和CRP相关. 高IL-23与较低HR相关 (p <0.05).

结论:

在晚期RA患者中,IL-23显著升高,这表明它与疾病进展有关.
虽然IL-17A和IL-17F水平可能与对照人群没有差异,但高IL-17A水平与疾病活性和血清标志物有关.
在晚期的RA中,IL-17F的过度产生比IL-17A的升高更频繁,而联合的细胞因子的过度产生不会放大个体的炎症效应.

关键词:

它们的IL-17A是IL-17A.它们的IL-17F是IL-17F.它们有IL-23和IL-23.疾病活动的疾病活动.类风湿性关节炎类风湿性关节炎

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