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Updated: Jul 14, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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在美国退伍军人中进行体质瘤下一代测序,这些退伍军人患有转移性前列腺癌

Luca F Valle1,2,3, Jiannong Li4, Heena Desai5,6

  • 1Radiation Oncology Service, Veterans Affairs (VA) Greater Los Angeles Healthcare System, Los Angeles, California.

JAMA network open
|May 12, 2025
PubMed
概括

转移性前列腺癌 (mPCa) 的基因组变化因种族而异. 下一代测序 (NGS) 确定了非西班牙裔黑人和白人退伍军人之间关键路径的差异,突出了对公平精确瘤学的需要.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...