基于唾液的激素诊断:进展,应用和未来的前景
Carolina Ruis Ferrari1, Samanta Mascarenhas Moraes1, Marília Afonso Rabelo Buzalaf1
1Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
Expert review of molecular diagnostics
|May 12, 2025
概括
唾液分析提供了一种非侵入性的激素检测方法,可以替代血液检测. 唾液诊断的进步正在增强其针对个性化医疗和疾病监测的潜力.
科学领域:
- 内分泌学 在内分泌学.
- 生物标志物发现发现
- 临床诊断 临床诊断 临床诊断
背景情况:
- 唾液是用于诊断的新兴生物液体,特别是用于激素分析.
- 它的非侵入性收集为基于血液的诊断提供了切实可行的替代方案.
- 唾液生物标志物反映了生理和病理条件.
研究的目的:
- 为了审查在唾液中可测量的激素.
- 检查唾液激素检测的分析方法.
- 探索唾液诊断的临床应用和挑战.
主要方法:
- 关于唾液激素分析的科学文献的综述.
- 检查包括酶链接免疫吸收检测 (ELISA),放射性免疫检测和液体染色学与协同质谱法 (LC-MS/MS) 结合的技术.
- 讨论优势,局限性和临床应用.
主要成果:
- 在唾液中确定了皮质醇,和雌激素等关键激素.
- 评估了各种分析方法的敏感性和挑战.
- 在压力监测,激素功能障碍诊断和个性化医学中突出临床用途.
结论:
- 唾液诊断显示了激素分析在临床和研究环境中的巨大潜力.
- 持续的研究和标准化对于克服荷尔蒙变异等挑战至关重要.
- 非侵入性唾液采集促进了个性化医学的诊断创新.
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