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相关概念视频

Methods of Sterilization II: Chemical Methods01:30

Methods of Sterilization II: Chemical Methods

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In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
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Methods of Sterilization I: Physical Methods01:29

Methods of Sterilization I: Physical Methods

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As used in a healthcare facility, sterilization destroys all microorganisms through physical or chemical methods. The physical method includes steam, dry heat, boiling water, and radiation.
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
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相关实验视频

Updated: May 16, 2025

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
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乙烯氧化物灭菌的参数过程控制:数据驱动的释放

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    乙烯氧化物 (EO) 灭菌中的参数释放可以使用统计过程控制来改进. 通过压力增量计算EO/水度为气体分析仪探针提供了可行的替代方案,提高了可靠性并减少了杀菌剂的使用.

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    科学领域:

    • 医疗器械灭菌 医疗器械灭菌
    • 工业微生物学 工业微生物学
    • 工艺工程是过程工程.

    背景情况:

    • 乙烯氧化物 (EO) 灭菌依赖于生物指标或参数释放 (PR) 根据ISO 11135:2014.
    • 当前的PR方法面临的挑战是气体分析仪探针用于测量EO度和湿度.
    • 根据ISO 11135:2014标准,基于EO度和湿度等控制参数来限制PR.

    研究的目的:

    • 评估统计过程控制以检测EO灭菌中的偏差.
    • 证明使用可靠的工艺数据用于PR.
    • 探索测量关键参数的替代方法.

    主要方法:

    • 来自100个常规EO灭菌周期的工艺数据的分析.
    • 室内相对湿度 (RH),温度和EO度的趋势.
    • 过程中获得的数据与气体分析仪探头测量的比较.

    主要成果:

    • 统计过程控制有效预测过程故障.
    • 通过压力增量计算EO/水度被证明是气体分析仪探针的可行替代方案.
    • 关键参数的变化减少,可以减少灭菌剂的使用.

    结论:

    • 统计过程控制提高了EO灭菌监测的可靠性.
    • 流程衍生数据,特别是通过压力增量,可以支持PR.
    • 优化参数控制导致更高效和潜在的更安全的灭菌过程.