艾滋病毒感染和长期COVID:一个RECOVER计划,基于电子健康记录的队列研究
Kellie L Hawkins1,2, Dima Dandachi3, Zoe Verzani4
1Public Health Institute at Denver Health, Denver, CO, USA.
概括
当使用计算表型定义时,艾滋病毒感染者患长期COVID的风险略高. 然而,在使用ICD-10代码时没有发现任何关联,这表明潜在的诊断不足.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 艾滋病毒感染者在感染SARS-CoV-2后可能面临长期COVID的高风险.
- 了解这种关联对于公共卫生战略和临床管理至关重要.
研究的目的:
- 研究艾滋病毒状况与患长期COVID的风险之间的关联.
- 为了比较长期COVID风险,使用不同诊断定义在艾滋病毒感染者和没有艾滋病毒感染者的个人.
主要方法:
- 利用了两个大型电子健康记录数据库 (PCORnet和N3C),数据从2018年1月1日到2024年4月30日.
- 包括超过460万名感染SARS-CoV-2的成年患者,根据艾滋病毒状况对其进行分类.
- 使用后勤回归来估计长期COVID的几率比率 (aOR),控制共变量并使用计算的表型和ICD-10代码定义.
主要成果:
- 使用计算的表型定义,在艾滋病毒感染者中观察到长期COVID几率的适度但显著增加 (PCORnet aOR 1.09;N3C aOR 1.18).
- 在使用ICD-10代码进行诊断时,没有发现艾滋病毒和长期COVID之间的显著关联 (PCORnet aOR 1.01;N3C aOR 1.07).
结论:
- 当被计算的表型定义时,艾滋病毒感染者表现出长期COVID的风险略有增加,但不是ICD-10代码.
- 研究结果表明,长期COVID可能在艾滋病毒感染者中未被充分认识到,这突出了那些患有先前存在的慢性疾病的人的诊断挑战.
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