在哺乳动物脏中,Dmrt2和Hmx2通过对抗性和辅助性调节过程,直接影响干细胞多样性

Riana K Parvez1, Doh Kyung Kim1, Réka L Csipán1

  • 1Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033.

概括

转录调节器Dmrt2和Hmx2/3对于脏干细胞 (IC) 亚型的规范至关重要. 它们的受限表达和相互抑制的相互作用建立了不同的IC身份,通过二碳酸盐输送物Slc4a1和Slc26a4.4控制pH平衡.

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