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在患有多发性硬化症的人群中,皮层病变和功能特定认知衰退的演变
Eva A Krijnen1,2, Julia Jelgerhuis1, Maureen Van Dam1
1MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
Neurology
|May 12, 2025
概括
多发性硬化症 (MS) 患者在10年内经历了认知能力的恶化,特别是注意力,口头记忆和执行功能 (EF). 皮质病变在基线和随着时间的推移与MS的认知衰退有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 多发性硬化症 (MS) 中的皮层病变显著影响认知,但它们的长期演变和对认知功能的特定影响尚不清楚.
- 了解皮层病变进展和认知衰退之间的关系对于管理MS进展至关重要.
研究的目的:
- 调查MS患者的功能特定认知功能的10年演变.
- 评估皮质损伤负荷和形成如何影响MS患者随时间推移的认知轨迹.
主要方法:
- 使用3TMRI (T1,FLAIR) 和10年的神经心理评估进行前性研究 (2008-2022).
- 评估了7个认知功能:注意力,执行功能 (EF),信息处理速度 (IPS),口语流,口语,视觉空间和工作记忆.
- 手动识别的皮层病变;用于分析病变负载和认知衰退的线性混合模型,按MS疾病阶段分层.
主要成果:
- 包括223名多发性硬化症患者和62名对照人群;94名多发性硬化症患者完成了10年的随访.
- 多发性硬化症患者在IPS和工作记忆中表现出基线缺陷;在10年内,注意力,口头记忆和EF下降最多.
- 基线皮质病变与注意力和口语流性下降相关;病变增加 (特别是晚期/进展性MS) 与口语流性下降相关.
结论:
- 多发性硬化症的认知能力在十年内恶化,影响注意力,口头记忆和EF,基线IPS和工作记忆障碍持续存在.
- 皮层病变负载和形成与认知能力下降有关,扩展损害到最初受影响较小的功能.
- 在MS中积累的皮质损伤导致认知缺陷随着时间的推移更广泛地传播.
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