鲁布斯 coreanus 提取物通过抑制TGF-β/Smad通路防止脏纤维化
Wencheng Jin1,2, Ara Cho3, Bogyeong Cho2
1Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.
PloS one
|May 12, 2025
概括
鲁布斯 coreanus 提取物 (MN705) 在小鼠模型和人类细胞中有效地预防纤维化. 这种天然化合物抑制了关键的纤维化通路,为病提供了潜在的治疗策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 自然产品研究 自然产品研究
背景情况:
- 纤维化是导致慢性病进展的重要因素.
- 鲁布斯 coreanus 以其抗氧化特性而闻名.
- 鉴定纤维化治疗的新型治疗剂至关重要.
研究的目的:
- 评估水溶性Rubus coreanus提取物 (MN705) 在预防纤维化的有效性.
- 在体内和体外模型中研究MN705的作用背后的机制.
主要方法:
- 一个单边尿路阻塞 (UUO) 鼠标模型被用于诱导纤维化.
- 人类脏近端管状上皮细胞 (HK-2) 在体外受到了TGF-β的挑战.
- 组织病理学分析 (马森的三色染色) 和西部斑点被用来评估纤维化和蛋白质表达.
主要成果:
- 在UUO小鼠模型中,MN705显著减轻了脏间歇性纤维化.
- 提取物减少了α-SMA蛋白的丰度,这是纤维化的一个标志物.
- 在体外,MN705降低了纤维素和-Smad2/3的表达,同时增加了TGF-β处理的HK-2细胞中的MnSOD.
结论:
- 鲁布斯 coreanus 提取物 (MN705) 显示出显著的抗纤维性作用.
- MN705抑制了与TGF-β相关的Smad和Smurf信号通路.
- 鲁布斯 (Rubus coreanus) 提取物是预防纤维化的潜在治疗候选物.
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