在养殖子中,Streptococcus bovis/Streptococcus equinus复杂相关脑膜炎的反复爆发
Megan J Crawford1, Kimberley N Sebastian2, Elizabeth Elsmo3
1College of Veterinary Medicine, Michigan State University, 784 Wilson Rd, East Lansing, Michigan 48824, USA.
Journal of comparative pathology
|May 12, 2025
概括
两次Streptococcus bovis/Streptococcus equinus复合体 (SBSEC) 爆发导致养殖子的神经疾病和死亡. 这是第一份报告,将SBSEC与这种物种的脑膜炎和败血症联系起来.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物病理学 动物病理学
背景情况:
- 杆菌bovis/Streptococcus equinus复合体 (SBSEC) 是动物和人类胃肠道中常见的一种细菌.
- 虽然通常是开始性,但SBSEC可以充当机会性病原体,导致严重的感染,如脑膜炎,内心炎和败血症.
- 之前关于SBSEC在子中引起疾病的报道很少见,只有一个记录的内心炎病例.
研究的目的:
- 记录和描述两个不同的SBSEC感染在养殖子中爆发的不同疫情.
- 在受影响的子种群中确定病原体和疾病的病理影响.
- 确定SBSEC是导致养殖子脑膜炎和败血症的病原体.
主要方法:
- 在连续两年内,在养殖子中发生了两个单独的疾病爆发的案例报告.
- 临床观察死亡前的神经症状.
- 受影响动物的尸检,组织病理学和有氧细菌培养,重点是大脑,肝脏,肺部和脏.
主要成果:
- 两次SBSEC感染爆发发生在一年间隔的养殖子中,死亡率显著 (2021年为5,000人,2022年为500人/100,000人).
- 受到影响的子表现出神经症状,肝壮病,壮病和肺部拥堵.
- 组织病理学证实了多个器官的性脑膜大脑炎和中性质炎症,在大脑和肝脏中发现了SBSEC分离体.
结论:
- 这项研究提供了第一个证据,表明Streptococcus bovis/Streptococcus equinus复合体 (SBSEC) 在养殖子中引起脑膜炎和败血症.
- SBSEC对养殖业构成重大威胁,能够导致大量死亡率和严重的神经疾病.
- 对子种群中SBSEC病原和控制策略的进一步研究是有必要的.
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