SARS-CoV-2 损害心肌细胞线粒体,并涉及长期的COVID相关心血管表现
Wenliang Che1, Shuai Guo2, Yanqun Wang3
1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Journal of advanced research
|May 12, 2025
概括
长期的COVID可能会导致严重的心脏问题,包括心肌炎,由于线粒体受损. 这项研究探讨了SARS-CoV-2感染后这些持续性心血管症状背后的细胞机制.
科学领域:
- 心脏病学 心脏病学
- 病理生理学 病理生理学
- 病毒免疫学 病毒免疫学
背景情况:
- 随着COVID-19大流行转变为流行病,需要继续关注长期COVID的心血管后果.
- 长期COVID心脏问题的潜在病理生理学仍然在很大程度上没有特征.
研究的目的:
- 在SARS-CoV-2感染后的个人中调查持续的心血管症状,称为长期COVID.
- 阐明导致长期COVID相关心脏功能障碍的细胞机制.
主要方法:
- 一系列病例描述了五名长期COVID患者的心血管结果.
- 内心肌活检与体化学染色用于肌心炎的确认.
- 电子显微镜检查心肌细胞超结构和线粒体完整性.
主要成果:
- 所有五名患者都被诊断为心肌炎,显示炎症细胞透.
- 电子显微镜揭示了心肌细胞中的线粒体真空化和肌纤维纤维降解.
- 在SARS-CoV-2感染的小鼠模型中观察到类似的线粒体和细胞变化.
结论:
- SARS-CoV-2 感染显著影响心脏组织中的线粒体完整性.
- 线粒体功能障碍是长期COVID的心血管并发症的一个关键因素.
- 研究结果提供了对长期COVID心脏病理学的细胞基础的见解.
更多相关视频
11:00Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
10.1K
03:45Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
3.0K
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
70
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
70
01:17Pathophysiology of Heart Failure
1.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.4K