在自闭症谱系障碍中脑脊液的特征 - - 一个系统的审查
Vandana Srivastava1, Christian O'Reilly2
1AI Institute, University of South Carolina, 5th floor, 1112 Greene St., Columbia, SC 29201, USA; Department of Computer Science and Engineering, University of South Carolina, 550 Assembly Street, Columbia, SC 29201, USA; Carolina Autism and Neurodevelopment Research Center, University of South Carolina, 1800 Gervais Street, Columbia, SC 29201, USA.
Neuroscience and biobehavioral reviews
|May 12, 2025
概括
在患有自闭症谱系障碍 (ASD) 的个体中,脑脊液 (CSF) 的组成不同,揭示了潜在的生物标志物. 需要进一步的研究来了解这些变化及其在ASD病因学中的作用.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 遗传学 遗传学 是一个
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,其原因仍在争论中.
- 包括免疫和肠道问题在内的生理因素与ASD病因有关.
- 大脑脊髓液 (CSF) 对于神经元平衡至关重要,其分析可以揭示神经系统疾病机制.
研究的目的:
- 系统地审查有关ASD患者中CSF属性和组成的现有文献.
- 确定与ASD相关的潜在的CSF生物标志物.
- 了解ASD如何改变脑脊髓组成及其对疾病起源和进展的影响.
主要方法:
- 在PubMed,Scopus和Web of Science (1977-2025) 的系统文献搜索.
- 手动选和选择49项相关研究.
- 与神经类型相比,在ASD人群中报告的CSF属性的分析.
主要成果:
- 在ASD患者中,在CSF免疫标记物,蛋白质,外轴性CSF,叶酸,催产素和血管压素中观察到显著的变化.
- 识别的文献差距包括年龄和样本大小的变化,以及性别偏见 (主要是男性参与者).
- 有限的研究专注于成年人群.
结论:
- 脑脊髓纤维的组成在患有自闭症的个体中显示出显著的差异,这表明潜在的生物标志物有用.
- 为了验证CSF生物标志物,对更大,更多样化的年龄和性别群体进行进一步的研究至关重要.
- 了解ASD中CSF的变化可以提高对其潜在机制和进展的了解.
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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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