肺功能下降和空气流限制风险在保持比率受损螺旋计 (PRISm) 亚型的吸烟状态下下降
Cuiqiong Dai1, Fan Wu2, Jia Tian3
1State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & Guangzhou Institute of Respiratory Health & National Center for Respiratory Medicine & Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.
呼吸前疾病综合征 (PRISm) 在吸烟者和不吸烟者中可能会先于COPD. 患有PRISm (NS-PRISm) 的不吸烟者和患有PRISm (ES-PRISm) 的经常吸烟者都显示出空气流量限制风险增加.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统健康 呼吸系统健康
- 流行病学 流行病学
背景情况:
- 呼吸前疾病综合征 (PRISm) 被认为是慢性阻塞性肺病 (COPD) 的前体.
- 然而,吸烟状态对从PRISm进展到COPD的影响仍然不完全理解.
研究的目的:
- 调查每年肺功能下降和发展空气流量限制的风险是否在PRISm亚型之间因吸烟状态而有所不同.
- 为了将这些结果与PRISm (NS-PRISm) 的永不吸烟者,PRISm (ES-PRISm) 的永不吸烟者和健康的对照组进行比较.
主要方法:
- 对一项为期15年的基于人口的前性队列研究的分析,涉及2850名参与者.
- 将参与者分为三组:正常对照组 (从未吸烟者和正常的脊髓测量),NS-PRISm和ES-PRISm.
- 在定义的群体中,每年肺功能下降率和空气流量限制的发生率的比较.
主要成果:
- 与NS-PRISm组相比,ES-PRISm组表现出每年肺功能下降的速度明显更快,以及发展空气流限制的风险更高.
- 与正常对照组相比,NS-PRISm和ES-PRISm组都显示出空气流限制的风险增加.
- 对ES-PRISm的进一步分析显示,与NS-PRISm相比,目前和前吸烟者患有PRISm的肺功能下降速度加快,空气流量限制风险增加.
结论:
- 研究结果表明,NS-PRISm和ES-PRISm都是COPD的潜在前体.
- 在COPD风险评估中,应考虑在吸烟者和非吸烟者群体中使用PRISm.
- 对PRISm的早期发现和干预对于预防COPD发展至关重要.
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