在胃癌中接受新辅助疗法后,瘤免疫微环境的重塑:更新和新的挑战
Fujing Sun1, Xiaozhuo Gao1, Tianming Li1
1Department of Pathology, Affiliated Cancer Hospital of Dalian University of Technology (Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University), Shenyang, China.
Biochimica et biophysica acta. Reviews on cancer
|May 12, 2025
概括
胃癌 (GC) 的新辅助疗法影响瘤的免疫微环境. 了解这些变化可以帮助预测治疗的有效性,并克服耐药性,以获得更好的患者结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 胃癌 (GC) 在全球具有很高的发病率和死亡率.
- 新辅助疗法 (NAC) 改善了GC患者的手术结果和生存率.
- 对新辅助疗法的不同患者反应需要进一步调查.
研究的目的:
- 审查新辅助疗法对GC瘤免疫微环境的影响.
- 确定用于预测新辅助疗法反应的生物标志物.
- 在GC新辅助疗法中阐明耐药性机制.
主要方法:
- 对临床前和临床证据的系统审查.
- 分析免疫细胞 (T细胞,B细胞,NK细胞) 在治疗疗效中的作用.
- 通过新辅助疗法探索免疫微环境调制.
主要成果:
- 新辅助疗法显著改变了GC中的瘤免疫微环境.
- 微环境中的免疫细胞群对于治疗反应至关重要.
- 有证据表明,基于免疫的生物标志物有可能预测治疗结果.
结论:
- 免疫微环境的调节是新辅助疗法在GC疗效的关键.
- 识别预测生物标志物和抵抗机制对于个性化GC治疗至关重要.
- 进一步的研究可以为GC患者推进个性化和精确的治疗策略.
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