埃皮卡捷可以预防与孕前相关的高血压和氧化应激
Luis J Soto1, Cecilia Del Tufiño1, Martha E Macias-Pérez1
1Escuela Superior de Medicina IPN, Mexico City, Mexico.
The journal of obstetrics and gynaecology research
|May 12, 2025
概括
在黑巧克力中发现的epicatechin有效地降低血压,并改善先兆子 (PE) 鼠标模型中的血管功能. 这些抗氧化剂的益处在怀孕后期服用时最为明显.
科学领域:
- 产科和妇科 产科和妇科
- 心血管研究研究心血管研究
- 营养科学 营养科学
背景情况:
- 孕前 (PE) 是一种常见且严重的妊娠并发症,影响多个器官系统,通常与血压调节受损有关.
- 一些抗氧化剂,如来自巧克力的甲,显示在管理高血压疾病的潜力.
研究的目的:
- 为了研究甲和黑巧克力 (DC) 的有效性,以逆转实验性预先怀孕症模型的血管反应性增加和氧化应激特征.
- 评估Epicatechin和DC对血压,血管收缩性和产前的氧化应激标志物的影响.
主要方法:
- 这项研究使用了一种患有妊娠前的老鼠模型.
- 在怀孕早期或晚期,老鼠口服接受了车载体,甲或黑巧克力 (DC).
- 测量包括血压 (尾巴袖囊),大动脉收缩率 (隔离器官浴) 和血清氧化应激标志物 (NADPH活性).
主要成果:
- 在孕前症模型中,使用epicatechin和DC显著降低了高血压.
- 用epicatechin和DC治疗导致腹腔大动脉收缩率降低.
- 观察到血清NADPH活性显著下降,表明氧化应激减少.
结论:
- 埃皮卡铁在孕前症中表现出显著的抗高血压作用.
- 甲的抗高血压作用归因于其抗氧化特性,改善血管收缩性.
- 晚期服用甲或黑巧克力产生了更明显的有益效果.
更多相关视频
12:00Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
19.0K
10:00Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
Published on: December 11, 2020
2.5K
相关概念视频
02:59Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
01:33Hormonal Regulation
32.7K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.7K
01:58Cell Specific Gene Expression
13.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.3K
02:07Oogenesis
63.2K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.2K