关于抗精神病药物对鱼类的潜在风险的关键见解,包括通过对行为的影响
Gabrielle Wasser-Bennett1, A Ross Brown1, Samuel K Maynard2
1Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, Devon, UK.
概括
抗精神病药物 (APD) 由于生物积累和行为变化,对鱼类构成环境风险. 目前的风险评估需要纳入这些机制,以便更准确地评估APD影响.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 药品在环境中的作用
背景情况:
- 抗精神病药物 (APD) 在全球水体中越来越多地被发现.
- 由于生物积累和鱼类的行为影响,一些APD带来了高的环境风险.
- 标准生态毒理学试验无法充分评估这些APD风险.
研究的目的:
- 批判性地审查APD对鱼类的环境风险.
- 探索评估鱼类APD的行为终点.
- 建议改善神经活性药物的环境风险评估 (ERA) 的方法.
主要方法:
- 阅读人类/哺乳动物数据以获得鱼类生态毒理学终点.
- 调查斑马鱼的行为表型,以评估APD.
- 在监管风险评估中评估行为数据的使用.
主要成果:
- APDs的行为影响可能会影响鱼类的健康状况和种群结果.
- 鱼类的表型可塑性需要考虑风险评估.
- 目前依赖于顶点终点的ERA方法对于神经活性药物来说是不够的.
结论:
- 需要一种精细的,机械的方法来实现APD强大的ERA.
- 纳入行为终点将改善环境风险评估.
- 解决APD风险需要更新生态毒理学测试策略.
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