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在非falciparum疟疾中急性损伤

Nicholas M Anstey¹, Matthew J Grigg¹, Timothy William²

¹Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia.

Seminars in nephrology

|May 12, 2025

概括

急性损伤 (AKI) 是非型疟疾的重要并发症,特别是Plasmodium knowlesi. 风险因素包括年龄,病原体包括血液溶解和管状亡,需要进一步研究长期结果.

科学领域:

热带医学热带医学
腎臟病學 (nephrology) 是一種醫學專業.
传染性疾病传染性疾病

背景情况:

急性损伤 (AKI) 是已知的疟疾并发症,特别是非类物种.
疟原虫 (Plasmodium knowlesi) 疟疾对AKI具有显著的风险,影响到20-30%的住院患者.
严重的AKI与已知疟疾的高死亡率有关.

研究的目的:

审查非法尔西帕鲁姆疟疾中AKI的发病率,发病因子和风险因素.
为了突出在Plasmodium vivax,Plasmodium malariae和Plasmodium ovale感染中缺乏特征的AKI风险.
强调需要研究AKI在非虫类疟疾中的长期结果.

主要方法:

文献综述和现有关于AKI在非falciparum疟疾中的研究的元分析.
对AKI的KDIGO (脏疾病:改善全球结果) 阶段分析.
检查病原遗传机制,包括血管内血液溶解和急性管状亡 (ATN).

主要成果:

45岁以上的年龄是AKI的六倍危险因素.
严重的AKI发生在约2.5%的已知疟疾住院病例中,并且与死亡率有关.
在P.vivax的AKI疟疾不那么严重,但在社区环境中发生约10%;病变发生通常与G6PD缺乏和8-氨基类药物有关.

结论:

在非类疟疾中,AKI是一个关键问题,其中P. knowlesi构成最高风险.
病原发生涉及血液溶解和ATN,并指出了类醇的潜在保护作用.
在这些感染中,AKI的长期后果仍然在很大程度上是未知的,需要进一步调查.

关键词:

据了解,我们知道Plasmodium.疟原虫的疟原虫.卵性原菌 (Plasmodium ovale) 是一种卵性原菌.这是一种活性菌 (Plasmodium vivax).急性脏损伤急性脏损伤慢性脏疾病慢性脏疾病

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