预测认知表现的生物衰老和志愿者参与之间的相互作用:来自协调认知评估协议研究的证据
Seoyoun Kim1,2, Xi Pan1
1Associate Professor, Department of Sociology, Texas State University.
概括
志愿服务通过减轻生物衰老的影响,有利于认知健康. 增加参与度,特别是每年超过100小时,可以加强这种保护性关系,防止认知能力下降.
科学领域:
- 老年学和认知神经科学
- 表观遗传学和衰老研究研究.
背景情况:
- 认知健康对于人口福祉和经济稳定至关重要.
- 由DNA甲基化 (DNAm) 标志着生物衰老,影响认知表现.
- 社会参与,特别是志愿服务,可能会改变表观遗传衰老对认知的影响.
研究的目的:
- 研究五个表观遗传钟与认知表现之间的关联.
- 确定志愿服务频率是否会改变表观遗传年龄加速和认知功能之间的关系.
主要方法:
- 在健康和退休研究中使用了协调认知评估协议.
- 评估了五个表观遗传时钟:Horvath,Hannum,PhenoAge,GrimAge和DunedinPoAm. 这五个表观遗传时钟包括在内.
- 通过志愿服务频率对表观遗传时钟-认知性能关联的效果修改.
主要成果:
- 任何级别的志愿服务与没有志愿服务相比,与更好的认知表现相关.
- 四个表观遗传时钟 (Horvath,PhenoAge,GrimAge,DunedinPoAm) 通过志愿服务显示了效果的改变.
- 特定的志愿服务时间 (每年1-100或101+小时) 缓解或减少了表观遗传年龄加速对认知的影响.
结论:
- 志愿者活动提供了显著的认知效益.
- 志愿服务频率与表观遗传衰老相互作用,影响认知表现.
- 志愿者参与的程度调整了表观遗传年龄和认知结果之间的关系.
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