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在水溶液中,塞马格卢提德聚合成寡合菌根和短纤维

Ian W Hamley¹, Lucas R de Mello¹, Valeria Castelletto¹

¹School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Whiteknights, Reading, Berkshire RG6 6AD, U.K.

Biomacromolecules

|May 12, 2025

概括

糖尿病和肥胖症药物塞马格卢提德可以聚合到溶液中的和纤维. 这种聚合会影响其稳定性,以及它如何影响肠膜的透性.

科学领域:

制药科学制药科学
生物物理化学生物物理化学
材料科学材料科学材料科学

背景情况:

塞马格卢提德是一种用于糖尿病和肥胖症的脂类药物.
脂可以自组装成纳米结构,可能导致聚合.
了解赛马格卢提德聚合对于其治疗应用和稳定性至关重要.

研究的目的:

为了研究在水溶液中塞马格卢提德的聚合行为.
为了描述由半化物聚合形成的纳米结构.
评估聚合对塞马格卢提德与生物膜相互作用的影响.

主要方法:

低温传导电子显微镜 (cryo-TEM) 用于可视化聚合物.
用于结构分析的小角度X射线散射 (SAXS).
分子动力学 (MD) 模拟以建模聚合过程.

主要成果:

在水中的高度下,塞马格卢提德会形成球形小粒.
还观察到一小部分针状纤维结合物.
较低度导致二聚体和三聚体的形成,而细胞在形成后是稳定的.
聚合改变了semaglutide对Caco-2细胞膜透性的影响.

结论:

在水溶液中,赛马格卢提德表现出度依赖的聚合.
观察到的聚合,特别是菌形成,随着时间的推移是稳定的.
赛马格卢提德聚合会影响其与肠道上皮细胞模型的相互作用,影响潜在的治疗疗效和配方稳定性.

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