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使用纳米-SiO₂-SO₃H作为有效的酸性催化剂,加速合成3-二基纳-4(1H) - 一衍生物

Habyl Naeemi¹, Nasrin Shadjou^2,3, Mehdi Mahmoudian^1,4

¹Department of Nanotechnology, Faculty of Chemistry, Urmia University, Urmia, Iran.

Scientific reports

|May 12, 2025

概括

一种新的纳米-SiO2-SO3H催化剂使用绿色,无溶剂的方法高效地合成2,3-二基纳-4(1H) 一衍生物. 这种可重复使用的催化剂提供了高产量和短的反应时间,推进了药物化学和可持续实践.

科学领域:

药用化学医学化学
材料科学材料科学材料科学
绿色化学绿色化学

背景情况:

2,3-dihydroquinazolin-4(1H) -one衍生物由于其多样化的生物活性,在药物化学中至关重要.
对于这些有价值的药物化合物,需要有效和快速的合成方法.
纳米催化剂为提高合成效率和可持续性提供了有希望的解决方案.

研究的目的:

准备和描述一种新的纳米-SiO2-SO3H催化剂.
为了利用这种催化剂来有效地合成2,3-二基纳-4(1H) -one衍生物的单合成.
评估开发的合成协议的可持续性和优势.

主要方法:

制备纳米-SiO2-SO3H通过对硫酸组对纳米颗粒的共价附着.
使用FE-SEM,TEM,FT-IR和EDAX进行催化剂的表征.
在没有溶剂的条件下在110°C的温度下使用异酸无水化物,芳香性化物和酸进行2,3-dihydroquinazolin-4(1H) -one衍生物的单合成.

主要成果:

纳米-SiO2-SO3H催化剂已成功合成和表征.
催化剂有效地促进了2,3-dihydroquinazolin-4(1H) -one衍生物的单合成,产量很好 (85-98%).
反应在无溶剂条件下进行,反应时间短 (5-20分钟),催化剂可轻松回收和重复使用.

结论:

开发的纳米-SiO2-SO3H催化剂对2,3-二基纳-4(1H) 一衍生物的绿色合成有效.
这种可持续的协议比传统方法具有显著的优势,包括无毒性和可重复使用性.
该研究强调了这种纳米催化剂在推进环境化学和制药研究方面的潜力.

关键词:

2,3-二基纳林-4(1H) -一个.先进的纳米材料是先进的.在纳米-SiO2-SO3H中.纳米催化剂的使用方法没有溶剂的条件.

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