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Updated: Jun 13, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
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Published on: January 30, 2014

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高分辨率的空间转录和细胞谱系分析揭示了在面发育过程中空间时细胞命运的决定

Jifan Feng1, Eva Janečková1, Tingwei Guo1

  • 1Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, 90033, USA.

Nature communications
|May 12, 2025
PubMed
概括

神经细胞 (CNCCs) 分化为介质细胞系,用于面发育. 这项研究绘制了小鼠口腔发育期间的CNCC衍生中细胞多样化图,揭示了口腔产生前的早期血统建立.

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Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography02:42

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相关概念视频

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...