中部早期青春期女孩的循环阿迪波金:系统性审查和元分析
Mei Jiang1, Ying Gao2, Ling Huang3
1Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Pediatric research
|May 12, 2025
概括
在中部早熟青春期 (CPP) 的女孩中观察到改变的阿迪波金水平,包括增加的勒素和减少的阿迪波涅丁. 早期预防肥胖对于这些孩子来说至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 儿科内分泌学 儿科内分泌学
- 代谢研究研究 代谢研究
背景情况:
- 中部早期青春期 (CPP) 涉及青春期的早期发作,影响生长和发育.
- 阿迪波金是脂肪组织中的信号蛋白,在新陈代谢和青春期调节中起作用.
- 改变的阿迪波金 (adipokine) 概况可能与CPP的发病和长期健康风险有关.
研究的目的:
- 系统地评估和比较被诊断患有CPP的女孩和健康对照者的循环阿迪波金水平.
- 为了确定在CPP女孩中显著改变的特定阿迪波金.
主要方法:
- 在主要数据库 (Embase,PubMed,Web of Science,Scopus,Cochrane Library) 进行了全面的文献搜索,截至2023年10月31日.
- 11项涉及701名CPP女孩和590名对照女孩的研究被纳入了元分析.
- 血清中的adiponectin,leptin,irisin,apelin,omentin,chemerin,resistin,vaspin和visfatin的水平进行了分析.
主要成果:
- 与对照组相比,患有CPP的女孩表现出明显升高的勒丁水平和降低的阿迪波内克水平.
- 虹膜素水平在两组之间没有显著差异.
- 丁协会的异质性与研究样本大小,CPP诊断标准和测量技术有关.
结论:
- 在处于中心早期青春期的女孩中,循环阿迪波金水平明显变化.
- 这些发现强调了预防患有CPP的儿童和青少年肥胖的重要性,原因是潜在的长期健康影响,包括心血管疾病风险.
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