抗的婴儿配方和抗酸药物:匹配还是不匹配?
Eline Tommelein1, Kyara Baert2, Mathieu Ombecq2
1Experimental Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Jette, Belgium. eline.tommelein@vub.be.
European journal of pediatrics
|May 12, 2025
概括
用胡卜豆 (CBG) 加厚的抗排泄婴儿配方比以粉为基础的更粘. 准备时间和抑制酸的兼容性是治疗一致性在管理婴儿吐的关键.
科学领域:
- 儿童营养学 儿童营养学
- 胃肠病学 胃肠病学
- 食品科学 食品科学 食品科学
背景情况:
- 婴儿配方奶粉使用加厚剂来控制反,但疗效因成分和胃状况而异.
- 一些加厚剂需要酸性来激活,可能受到胃酸抑制剂的阻碍.
研究的目的:
- 评估基于不同加厚剂的抗吐 (AR) 婴儿配方奶粉的粘度及其随时间和pH的稳定性.
- 评估AR配方与常见反流药物的兼容性.
主要方法:
- 在不同的pH值和时间条件下,使用旋转风力计测量了五种婴儿配方奶粉 (一个参考,四个AR) 的粘度.
- 配方包括不同的加厚剂 (例如,胡卜豆,粉) 和蛋白质成分.
主要成果:
- 所有测试的AR配方都比参考配方具有更高的粘度.
- 基于胡卜豆 (CBG) 的配方通常比基于粉的配方具有更高的粘度.
- 凯赛因占主导地位的配方在酸性条件下增加了粘度,随着时间的推移,效果会减弱;中等酸度 (pH4) 影响粘度最小.
结论:
- 基于CBG的AR配方需要至少30分钟的准备时间才能达到最佳粘度.
- 用CBG加厚的配方保持着比以粉为基础的配方更高的粘度,即使在酸性抑制下.
- 基于素的加厚仍然有效与抑制酸的药物,可能减缓粘度降低.
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