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Updated: May 14, 2025

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使用基于深度学习的方法发现了新的GluN1/GluN3ANMDA受体抑制剂

Shi-Hang Wang1,2, Yue Zeng3,4,5, Hao Yang1,2

  • 1Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, China.

Acta pharmacologica Sinica
|May 12, 2025
PubMed
概括

我们使用人工智能发现了GM-10,一种针对GluN1/GluN3A受体的新候选药物. 这种新型抑制剂是使用脚手架跳跃发现的,这是一种寻找具有类似活性但结构不同的药物的方法.

关键词:
在N-甲基-D-亚斯巴酸盐受体.双子座的摩尔是双子座的摩尔.在GluN1/GluN3A中使用.深度学习是一种深度学习.基于联结体的虚拟选.在脚手架上跳跃跳跃.

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