由于肠道微生物群的增加,酸会在衰老过程中诱导内皮细胞衰老
Seyed Soheil Saeedi Saravi1,2, Benoit Pugin3, Florentin Constancias3
1Center for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland. soheil.saeedi@uzh.ch.
Nature aging
|May 12, 2025
概括
肠道细菌的代谢物酸 (PAA) 驱动了老化中的内皮细胞衰老. 降低酸盐水平会损害其保护作用,这表明酸是健康衰老的潜在疗法.
科学领域:
- 微生物学 微生物学
- 老年学是指老年学的学科.
- 心血管生物学 心血管生物学
背景情况:
- 内皮细胞衰老有助于心血管衰老.
- 诱导体内衰老的机制在很大程度上是未知的.
研究的目的:
- 调查与衰老和内皮衰老相关的肠道微生物代谢物.
- 确定潜在的基于微生物组的老年疗法.
主要方法:
- 在老年人和小鼠中测量了酸 (PAA) 和酸乙胺 (PAGln).
- 进行了基因组分析,以确定PAA产生途径和细菌.
- 殖民后的年轻小鼠感染了Clostridium sp. ASF356 (Clos) 和评估的PAA水平,内皮衰老和血管功能.
- 研究了PAA通过线粒体H2O2生产的机制.
- 评估便中酸盐水平和Sirt1依赖的炎症调节和氧化还原平衡.
主要成果:
- 在老年人和小鼠中,PAA和PAGln的水平较高.
- 密集殖民增加了血液PAA,诱导了内皮衰老和血管生成受损.
- PAA通过线粒体H2O2触发衰老,从而恶化了与衰老相关的分泌表型.
- 便中酸盐水平随着年龄的增长而下降,从而降低了其老化和抗炎功能.
结论:
- 在衰老中,PAA调解了肠血管交叉通话.
- 降低的酸盐损害了对抗衰老的保护机制.
- 酸显示出作为促进健康衰老的基于微生物群的老年疗法的潜力.
更多相关视频
13:59A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
Published on: August 12, 2018
8.0K
08:52Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
3.4K
相关概念视频
01:26Aging
29
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
29
01:37Mitochondria
8.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
8.9K
01:38Inflammation
51.7K
Overview
51.7K