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Updated: May 16, 2025

Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations

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Published on: November 7, 2019

在喉状细胞癌中基于转录学探索与ubiquitination相关的生物标志物和潜在的分子机制

Qiu Chen^1,2, Zhimin Wu¹, Yifei Ma³

¹School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, 550004, China.

BMC medical genomics

|May 12, 2025

概括

这项研究确定了四种新的生物标志物 (WDR54,KAT2B,NBEAL2,LNX1),这些生物标志物与喉状细胞癌 (LSCC) 检测的随处可见性相关基因有关. 这些发现为改善临床诊断和了解LSCC分子机制提供了潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

喉平细胞癌 (LSCC) 是一种流行癌症,死亡率很高.
在LSCC的发展和进展中,乌比基化起着至关重要的作用.
确定LSCC可靠的生物标志物对于早期诊断和治疗至关重要.

研究的目的:

在LSCC中识别和验证与无处不在相关基因 (UbRGs) 相关的新生物标志物.
探索LSCC的诊断价值和潜在的治疗目标.
阐明LSCC发展背后的分子机制.

主要方法:

差异表达分析和加权基因共表达网络分析 (WGCNA) 用于识别候选基因.
机器学习算法从交叉的基因组 (DEGs,WGCNA模块,UbRGs) 中选出潜在的生物标志物.
使用RT-qPCR和公共数据集 (TCGA-LSCC,GSE127165) 进行生物标志物验证,通过ROC曲线评估诊断准确度.

主要成果:

四个生物标志物 (WDR54,KAT2B,NBEAL2,LNX1) 被确定并验证,显示LSCC中一致的表达趋势.
这些生物标志物在预测LSCC的临床方面表现出显著的准确性.
相关癌症包括恶性瘤和结直肠癌,确定了潜在的治疗药物和调节性转录因子.

结论:

与UbRG相关的已识别的生物标志物 (WDR54,KAT2B,NBEAL2,LNX1) 对LSCC的临床诊断有很大的前景.
这些生物标志物为LSCC的分子机制提供了洞察力.
进一步的研究可以利用这些发现来针对LSCC治疗和改善患者的治疗结果.

关键词:

生物标志物生物标志物喉皮状细胞癌的癌症.监管网络监管网络是指监管网络的组成部分.与乌比基因化相关的基因在WGCNA中,WGCNA是WGCNA.

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