抑郁症状,成人时体重指数变化模式和全因死亡风险之间的相互作用:基于人口的研究
Zhixiao Xu1, Chengshui Chen2,3,4, Xiong Lei5
1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
BMC psychiatry
|May 12, 2025
概括
成年人体重指数 (BMI) 的变化显著影响抑郁症风险. 特定的BMI变化模式,特别是高的增加,与更高的抑郁率有关,并调解抑郁症状和死亡率之间的关系.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心理健康研究 心理健康研究
背景情况:
- 新出现的证据表明,成人体重指数 (BMI) 变化模式对于理解抑郁症至关重要.
- 这项研究调查了成人BMI变化模式对抑郁症发展的影响.
研究的目的:
- 评估成人BMI变化模式对抑郁症的影响.
- 检查BMI变化模式在抑郁症状和全因死亡率之间的关联中的作用.
主要方法:
- 利用了国家健康和营养检查调查 (2007-2018) 对10,448名参与者的数据.
- 采用后勤回归,通用线性模型,考克斯比例危险模型和调解分析.
- 评估了BMI变化模式,抑郁症状 (PHQ-9) 和全因死亡率之间的关系.
主要成果:
- 较高的BMI增加模式与不超重模式相比,抑郁症的几率是1.61倍.
- 较高的患者健康问卷-9 (PHQ-9) 评分与增加全因死亡风险相关 (HR:1.03).
- 成年人BMI变化模式中介于抑郁症状与全因死亡率之间的联系的26.98%.
结论:
- 成年人持续肥胖会增加抑郁症的风险,而BMI变化模式起着调解作用.
- 针对有风险的BMI变化模式的早期干预可以减少抑郁症的发生率.
- 需要进一步的研究来确定修改BMI变化模式是否可以降低抑郁率.
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