蛋白氨酸酸酶受体类型卡帕 (PTPRK) 修订:对结构,功能和病理学的不断演变的见解
Chen Zheng1,2, Ting Liu1, An Qi Wang1
1School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Journal of translational medicine
|May 12, 2025
概括
蛋白氨酸酸酶受体类型卡帕 (PTPRK) 是一种参与细胞信号和免疫反应的瘤抑制剂. 恢复 PTPRK 活性可能提供新的癌症疗法并克服药物耐药性.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 蛋白氨酸酸酶受体类型卡帕 (PTPRK) 是由染色体6q编码的膜结合的氨酸酸酶.
- PTPRK在细胞信号传递,粘附,免疫反应和神经发育中发挥着关键作用.
- 它在各种癌症中表现出抑制瘤的特性,包括结直肠癌,肺癌,卵巢癌和黑色素瘤.
研究的目的:
- 阐明PTPRK在细胞信号传递和疾病发病过程中的结构特征和功能作用.
- 探索PTPRK在癌症,免疫调节和神经功能中的参与.
- 突出PTPRK作为癌症和其他疾病的潜在治疗点.
主要方法:
- 本综述综合了关于PTPRK结构,功能和疾病关联的现有文献.
- 分析PTPRK在脱化关键信号分子 (例如EGFR,STAT3,β-catenin) 的作用.
- 研究PTPRK在免疫细胞发育和神经退行性疾病中的参与.
主要成果:
- PTPRK经历蛋白质分解裂变,产生调节核β-catenin信号的功能子单元.
- 通过去酸化关键标,PTPRK抑制癌细胞的增殖,存活和转移.
- PTPRK与CD4+T细胞发育,自身免疫性疾病 (多发性硬化症) 和神经退行性疾病 (阿尔茨海默病) 有关.
结论:
- PTPRK是一种多方面的蛋白质,在抑制癌症,免疫调节和神经系统功能方面发挥着重要作用.
- 疾病间PTPRK表达和活性的变异性表明了复杂的调节机制.
- 向PTPRK活动为各种人类疾病提供了一个有希望的治疗策略,包括癌症和耐药性.
相关概念视频
01:26Receptor Tyrosine Kinases
11.9K
Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
11.9K
02:54Protein Kinases and Phosphatases
12.9K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
12.9K
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.3K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.3K
01:00Enzyme-linked Receptors
76.5K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
76.5K
01:22Amplifying Signals via Enzymatic Cascade
8.2K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
8.2K
01:15G Protein-coupled Receptors
10.9K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
10.9K