家庭腺多重症中的心理健康:系统性审查
M J Mol1,2,3,4, H Bouchiba1,2,3, A S Aelvoet1,2,3
1Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Psycho-oncology
|May 13, 2025
概括
家庭腺瘤多重症 (FAP) 患者可能有更高的精神疾病和智力缺陷率. 在遗传性癌症综合征的基因检测和手术期间,痛苦和焦虑症状可能会增加.
科学领域:
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
- 精神病学是一个精神病学.
背景情况:
- 家族性腺瘤多重症 (FAP) 是一种遗传性疾病,在没有干预的情况下,结直肠癌的风险接近100%.
- 对FAP患者来说,终身监测和预防性手术是标准的,这给生活带来了重大挑战.
- 患有FAP患者的孩子有50%的风险继承这种疾病.
研究的目的:
- 系统地审查有关FAP患者心理健康问题的文献.
- 在FAP中调查焦虑,抑郁,痛苦,智力障碍和自闭症谱症状的患病率.
- 评估与FAP管理相关的心理负担.
主要方法:
- 在PubMed,EMBASE和Cochrane图书馆进行了全面的文献搜索.
- 包括从创立到2024年5月发表的英语研究.
- 该审查重点关注FAP患者的心理健康结果.
主要成果:
- 在2045篇确定论文中,有35篇符合纳入标准.
- 大多数研究都没有发现平均痛苦,焦虑或抑郁症得分的显著增加.
- 小组在基因测试和手术周围经历了增加的痛苦,焦虑和抑郁.
- 建议FAP与同时出现的精神疾病和较低的认知功能之间的关联.
结论:
- 一些证据表明,与普通人群相比,FAP患者的精神疾病和智力缺陷的患病率更高.
- 痛苦,焦虑和抑郁症状可能在关键医疗程序期间在特定的FAP患者亚组中升高.
- 由于FAP的罕见性和小样本大小,需要进一步的大规模前性研究来得出关于心理健康结果的确切结论.
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